Title : Pyrroloquinoline quinine inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos in mouse bone marrow cells and inhibits wear particle-induced osteolysis in mice.

Pub. Date : 2013

PMID : 23613773






4 Functional Relationships(s)
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1 The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study. PQQ Cofactor tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
2 PQQ inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. PQQ Cofactor tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
3 The mRNA expression of c-Fos, NFATc1, and TRAP in RANKL-treated BMMs was inhibited by PQQ treatment. PQQ Cofactor tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
4 Moreover, RANKL-induced c-Fos and NFATc1 protein expression was suppressed by PQQ. PQQ Cofactor tumor necrosis factor (ligand) superfamily, member 11 Mus musculus