Pub. Date : 2013 Aug 9
PMID : 23612072
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 2 | 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 3 | Further analysis using microarray gene profiling and Connectivity Map analysis showed that MCF-7 cells treated with 6-shogaol display gene expression signatures characteristic of peroxisome proliferator activated receptor gamma (PPARgamma) agonists, suggesting that 6-shogaol may activate the PPARgamma signaling pathway for its antitumor effects. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 4 | Further analysis using microarray gene profiling and Connectivity Map analysis showed that MCF-7 cells treated with 6-shogaol display gene expression signatures characteristic of peroxisome proliferator activated receptor gamma (PPARgamma) agonists, suggesting that 6-shogaol may activate the PPARgamma signaling pathway for its antitumor effects. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 5 | Further analysis using microarray gene profiling and Connectivity Map analysis showed that MCF-7 cells treated with 6-shogaol display gene expression signatures characteristic of peroxisome proliferator activated receptor gamma (PPARgamma) agonists, suggesting that 6-shogaol may activate the PPARgamma signaling pathway for its antitumor effects. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 6 | Further analysis using microarray gene profiling and Connectivity Map analysis showed that MCF-7 cells treated with 6-shogaol display gene expression signatures characteristic of peroxisome proliferator activated receptor gamma (PPARgamma) agonists, suggesting that 6-shogaol may activate the PPARgamma signaling pathway for its antitumor effects. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 7 | Further analysis using microarray gene profiling and Connectivity Map analysis showed that MCF-7 cells treated with 6-shogaol display gene expression signatures characteristic of peroxisome proliferator activated receptor gamma (PPARgamma) agonists, suggesting that 6-shogaol may activate the PPARgamma signaling pathway for its antitumor effects. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 8 | Indeed, treatment of MCF-7 and HT29 cells with 6-shogaol induced PPARgamma transcriptional activity, suppressed NFkappaB activity, and induced apoptosis in breast and colon cancer cells in a PPARgamma-dependent manner. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 9 | Indeed, treatment of MCF-7 and HT29 cells with 6-shogaol induced PPARgamma transcriptional activity, suppressed NFkappaB activity, and induced apoptosis in breast and colon cancer cells in a PPARgamma-dependent manner. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 10 | Furthermore, 6-shogaol is capable of binding to PPARgamma with a binding affinity comparable to 15-delta prostaglandin J2, a natural ligand for PPARgamma. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 11 | Furthermore, 6-shogaol is capable of binding to PPARgamma with a binding affinity comparable to 15-delta prostaglandin J2, a natural ligand for PPARgamma. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 12 | Together, our findings suggest that the antitumor effects of 6-shogaol are mediated through activation of PPARgamma and imply that activation of PPARgamma might be beneficial for breast and colon cancer treatment. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 13 | Together, our findings suggest that the antitumor effects of 6-shogaol are mediated through activation of PPARgamma and imply that activation of PPARgamma might be beneficial for breast and colon cancer treatment. | shogaol | peroxisome proliferator activated receptor gamma | Homo sapiens |