Title : Estrogen receptor α is the major driving factor for growth in tamoxifen-resistant breast cancer and supported by HER/ERK signaling.

Pub. Date : 2013 May

PMID : 23609470






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Increased expression of EGFR and increased phosphorylation of HER3 were observed upon acquisition of tamoxifen resistance, and the extracellular activated kinase (ERK) signaling pathway was highly activated in the resistant cells. Tamoxifen epidermal growth factor receptor Homo sapiens
2 The EGFR inhibitor gefitinib and the ERK pathway inhibitor U0126 resulted in partial and preferential growth inhibition of tamoxifen-resistant cells. Tamoxifen epidermal growth factor receptor Homo sapiens