Title : Positive regulation of osteogenesis by bile acid through FXR.

Pub. Date : 2013 Oct

PMID : 23609136






1 Functional Relationships(s)
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1 In vitro, activation of FXR by bile acids (chenodeoxycholic acid [CDCA] or 6-ECDCA) or FXR agonists (GW4064 or Fexaramine) significantly enhanced osteoblastic differentiation through the upregulation of Runx2 and enhanced extracellular signal-regulated kinase (ERK) and beta-catenin signaling. obeticholic acid nuclear receptor subfamily 1, group H, member 4 Mus musculus