Title : mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.

Pub. Date : 2013 Jul

PMID : 23607966






1 Functional Relationships(s)
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1 The clinically available adenosine monophosphate-activated protein kinase activator, metformin, which is an antidiabetic drug, prevents rapamycin-induced ERK activation and the development of mechanical hypersensitivity and spontaneous pain. Sirolimus mitogen-activated protein kinase 1 Homo sapiens