Title : Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and μ-receptors.

Pub. Date : 2013 Dec

PMID : 23598399






2 Functional Relationships(s)
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1 The obtained results showed that intra-dPAG administration of morphine significantly increased escape latency, a panicolytic-like effect that was blocked by pre-treatment with intra-dPAG injection of either naloxone or the 5-HT1A antagonist N-[2-[4-(2-methoxyphenyl)-1 piperazinyl] ethyl] -N- 2- pyridinyl-ciclohexanecarboxamide maleate (WAY-100635). dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 These results suggest a synergic interaction between the 5-HT1A and the micro-opioid receptor at post-synaptic level on neurons of the dPAG that regulate proximal defense, theoretically related to panic attacks. dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus