Title : The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans.

Pub. Date : 2013

PMID : 23593335






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans. Sulfur NFS1 cysteine desulfurase Homo sapiens
2 In humans, the L-cysteine desulfurase NFS1 plays a crucial role in the mitochondrial iron-sulfur cluster biosynthesis and in the thiomodification of mitochondrial and cytosolic tRNAs. Sulfur NFS1 cysteine desulfurase Homo sapiens
3 We have previously demonstrated that purified NFS1 is able to transfer sulfur to the C-terminal domain of MOCS3, a cytosolic protein involved in molybdenum cofactor biosynthesis and tRNA thiolation. Sulfur NFS1 cysteine desulfurase Homo sapiens
4 Purified NFS1 was used to reconstitute the lacking molybdoenzyme activity of the Neurospora crassa nit-1 mutant, giving additional evidence that NFS1 is the sulfur donor for Moco biosynthesis in eukaryotes in general. Sulfur NFS1 cysteine desulfurase Homo sapiens
5 Purified NFS1 was used to reconstitute the lacking molybdoenzyme activity of the Neurospora crassa nit-1 mutant, giving additional evidence that NFS1 is the sulfur donor for Moco biosynthesis in eukaryotes in general. Sulfur NFS1 cysteine desulfurase Homo sapiens