Pub. Date : 2013 May
PMID : 23590198
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PON1 Q192R and L55M polymorphisms and organophosphate toxicity risk: a meta-analysis. | Organophosphates | paraoxonase 1 | Homo sapiens |
| 2 | Serum paraoxonase (PON1) is an esterase that is involved in the detoxification of organophosphate insecticides. | Organophosphates | paraoxonase 1 | Homo sapiens |
| 3 | Emerging lines of evidence have shown that functional polymorphisms in the PON1 gene might play a critical role in increasing susceptibility to organophosphate toxicity, but individually published studies showed inconclusive results. | Organophosphates | paraoxonase 1 | Homo sapiens |
| 4 | This meta-analysis aimed to derive a more precise estimation of the associations between the PON1 polymorphisms and organophosphate toxicity risk. | Organophosphates | paraoxonase 1 | Homo sapiens |
| 5 | The meta-analysis results showed that the PON1 192Q and 55L polymorphisms may increase the risk of organophosphate toxicity. | Organophosphates | paraoxonase 1 | Homo sapiens |
| 6 | Further subgroup analyses by ethnicity showed significant associations of the PON1 192Q and 55L polymorphisms with increased risk of organophosphate toxicity among the Caucasian populations. | Organophosphates | paraoxonase 1 | Homo sapiens |
| 7 | In conclusion, the current meta-analysis indicates that the PON1 192Q and 55LM polymorphisms may increase the risk of organophosphate toxicity, especially among the Caucasian populations. | Organophosphates | paraoxonase 1 | Homo sapiens |