Title : Cognitive function, plasma MnSOD activity, and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls.

Pub. Date : 2014 May

PMID : 23588476






6 Functional Relationships(s)
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1 Cognitive function, plasma MnSOD activity, and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls. ala-9val superoxide dismutase 2 Homo sapiens
2 The functional Ala-9Val polymorphism of the mitochondrial enzyme manganese superoxide dismutase (MnSOD), which detoxifies superoxide radicals to hydrogen peroxide, has been associated with schizophrenia. ala-9val superoxide dismutase 2 Homo sapiens
3 We recruited 923 schizophrenic inpatients and 566 healthy controls and compared them on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), plasma MnSOD activity, and the MnSOD Ala-9Val polymorphism. ala-9val superoxide dismutase 2 Homo sapiens
4 We showed that the MnSOD Ala-9Val polymorphism may not contribute directly to the susceptibility to schizophrenia. ala-9val superoxide dismutase 2 Homo sapiens
5 The association between higher MnSOD activity and cognitive impairment in schizophrenia is dependent on the MnSOD Ala-9Val polymorphism. ala-9val superoxide dismutase 2 Homo sapiens
6 The association between higher MnSOD activity and cognitive impairment in schizophrenia is dependent on the MnSOD Ala-9Val polymorphism. ala-9val superoxide dismutase 2 Homo sapiens