Title : Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells.

Pub. Date : 2013 Jul

PMID : 23585020






4 Functional Relationships(s)
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Protein Name
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1 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). Phosphoribosyl Pyrophosphate uridine monophosphate synthetase Homo sapiens
2 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). Phosphoribosyl Pyrophosphate uridine monophosphate synthetase Homo sapiens
3 A possible explanation for inhibition of UMP synthase activity by AICAr was a depression in cellular levels of PRPP, a substrate of UMP synthase. Phosphoribosyl Pyrophosphate uridine monophosphate synthetase Homo sapiens
4 A possible explanation for inhibition of UMP synthase activity by AICAr was a depression in cellular levels of PRPP, a substrate of UMP synthase. Phosphoribosyl Pyrophosphate uridine monophosphate synthetase Homo sapiens