Title : Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway.

Pub. Date : 2013 Jun

PMID : 23563640






2 Functional Relationships(s)
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1 The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P<0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P<0.01, respectively). Curcumin vimentin Homo sapiens
2 The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P<0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P<0.01, respectively). Curcumin vimentin Homo sapiens