Title : Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.

Pub. Date : 2013 Apr 4

PMID : 23559002






2 Functional Relationships(s)
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1 Notably, blocking superoxide production attenuated JNK activation as well as cell death induced by simvastatin. Superoxides mitogen-activated protein kinase 8 Homo sapiens
2 Taken together, our data highlight the critical role of non-canonical regulation of Rho GTPases and involvement of downstream superoxide-mediated activation of JNK pathway in the anticancer activity of simvastatin, which would have potential clinical implications. Superoxides mitogen-activated protein kinase 8 Homo sapiens