Title : Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice.

Pub. Date : 2013 Jun

PMID : 23547261






1 Functional Relationships(s)
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1 The expression of the master antioxidant regulatory factor Nrf2 (nuclear factor erythroid 2-related factor 2) and its targets, Sesn2, Prdx3, Gclc, and Gclm, was decreased in beta-Bmal1(-/-) islets, which may contribute to the observed increase in ROS accumulation. Reactive Oxygen Species aryl hydrocarbon receptor nuclear translocator-like Mus musculus