Pub. Date : 2013 Jun
PMID : 23538902
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. | XL 888 | NRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | The HSP90 inhibitor XL888 is effective at reversing BRAF inhibitor resistance in melanoma, including that mediated through acquired NRAS mutations. | XL 888 | NRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | The present study has investigated the mechanism of action of XL888 in NRAS-mutant melanoma. | XL 888 | NRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | In an animal xenograft model of NRAS-mutant melanoma, XL888 treatment led to reduced tumor growth and apoptosis induction. | XL 888 | NRAS proto-oncogene, GTPase | Homo sapiens |