Title : Over-production of nitric oxide by oxidative stress-induced activation of the TGF-β1/PI3K/Akt pathway in mesangial cells cultured in high glucose.

Pub. Date : 2013 Apr

PMID : 23524565






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1 CONCLUSION: The results demonstrate that high glucose causes oxidative stress and NO over-production in rat mesangial cells in vitro via decreasing Bim and increasing iNOS, which are at least partially mediated by the TGF-beta1/PI3K/Akt pathway. Glucose nitric oxide synthase 2 Rattus norvegicus