Pub. Date : 2013 Aug
PMID : 23506745
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pre-administration of naringenin significantly reduced the severity of colitis and resulted in down-regulation of pro-inflammatory mediators (inducible NO synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), cyclo-oxygenase-2 (Cox2), TNF-alpha and IL-6 mRNA) in the colon mucosa. | naringenin | tumor necrosis factor | Mus musculus |
| 2 | In addition, in vitro NF-kappaB reporter assays performed on human colonic HT-29 cells exposed to naringenin demonstrated a significant inhibition of TNF-alpha-induced NF-kappaB luciferase expression. | naringenin | tumor necrosis factor | Mus musculus |