Title : Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts.

Pub. Date : 2013 May 15

PMID : 23500546






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 It was found that mRNA, protein, and current density of K(Ca)3.1 channels were greatly enhanced in cultured cardiac fibroblasts treated with 1 muM Ang II, and the effects were countered by the angiotensin type 1 receptor (AT1R) blocker losartan, the p38-MAPK inhibitor SB203580, the ERK1/2 inhibitor PD98059, and the PI3K/Akt inhibitor LY294002. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one angiotensin II receptor, type 1a Rattus norvegicus
2 It was found that mRNA, protein, and current density of K(Ca)3.1 channels were greatly enhanced in cultured cardiac fibroblasts treated with 1 muM Ang II, and the effects were countered by the angiotensin type 1 receptor (AT1R) blocker losartan, the p38-MAPK inhibitor SB203580, the ERK1/2 inhibitor PD98059, and the PI3K/Akt inhibitor LY294002. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one angiotensin II receptor, type 1a Rattus norvegicus