Pub. Date : 2013 Jun 1
PMID : 23500539
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thalidomide inhibits fibronectin production in TGF-beta1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway. | Thalidomide | fibronectin 1 | Homo sapiens |
| 2 | The aims were to examine possible therapeutic effects of thalidomide on fibronectin expression in transforming growth factor-beta1 (TGF-beta1)-treated normal fibroblasts (NFs) and keloid-derived fibroblasts (KFs) and the underlying mechanism of action, especially the involvement of mitogen-activated protein kinase (MAPKs) and Sma- and Mad-related family (Smads) pathways. | Thalidomide | fibronectin 1 | Homo sapiens |
| 3 | TGF-beta1 induced significant fibronectin expression in NFs and KFs and the effect was inhibited by pretreatment with thalidomide. | Thalidomide | fibronectin 1 | Homo sapiens |
| 4 | In addition, thalidomide pretreatment inhibited the TGF-beta-induced DNA binding activity of AP-1 and Smad3/4, caused fibronectin degradation by increasing the activity of matrix metalloproteinase 9, and decreased production of TGF-beta1 and fibronectin and the number of fibroblasts in an in vivo keloid model. | Thalidomide | fibronectin 1 | Homo sapiens |
| 5 | In addition, thalidomide pretreatment inhibited the TGF-beta-induced DNA binding activity of AP-1 and Smad3/4, caused fibronectin degradation by increasing the activity of matrix metalloproteinase 9, and decreased production of TGF-beta1 and fibronectin and the number of fibroblasts in an in vivo keloid model. | Thalidomide | fibronectin 1 | Homo sapiens |