Title : A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Pub. Date : 2013 Jun 14

PMID : 23500098






3 Functional Relationships(s)
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1 A peroxisome proliferator-activated receptor-delta agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson"s disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine peroxisome proliferator activator receptor delta Mus musculus
2 Striatal PPARdelta levels were increased (over two-fold) immediately after MPTP treatment (30 mg/kg for 5 consecutive days) compared to saline-treated mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine peroxisome proliferator activator receptor delta Mus musculus
3 These results indicate that agonism of PPARdelta provides protection against MPTP toxicity, in agreement with the effects of other PPAR agonists. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine peroxisome proliferator activator receptor delta Mus musculus