Pub. Date : 1975 Feb
PMID : 234821
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide. | Hydrochlorothiazide | renin | Canis lupus familiaris |
| 2 | When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered. | Hydrochlorothiazide | renin | Canis lupus familiaris |
| 3 | These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic. | Hydrochlorothiazide | renin | Canis lupus familiaris |