Title : Statins suppress glucose-induced plasminogen activator inhibitor-1 expression by regulating RhoA and nuclear factor-κB activities in cardiac microvascular endothelial cells.

Pub. Date : 2013 Jan

PMID : 23479762






1 Functional Relationships(s)
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1 PAI-1 mRNA and protein expression levels were both increased with high glucose concentrations, but they were significantly suppressed by simvastatin and atorvastatin treatment (P < 0.01) and the effects were reversed by mevalonate (100 mumol/L) and geranylgeranyl pyrophosphate (10 mumol/L) but not farnesyl pyrophosphate (10 mumol/L). Mevalonic Acid serpin family E member 1 Homo sapiens