Pub. Date : 2013
PMID : 23469098
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For this, ATP/P2Y1 receptor-mediated mechanisms were required because the IL-6 production was (i) inhibited by a P2Y1 receptor antagonist, MRS2179, (ii) abolished in astrocytes obtained from P2Y1 receptor-knockout mice, and (iii) mimicked by exogenously applied ATP. | Adenosine Triphosphate | interleukin 6 | Mus musculus |
| 2 | Taken together, when astrocytes sense MeHg, they release ATP that autostimulates P2Y1 receptors to upregulate IL-6, thereby leading to A1 receptor-mediated neuro-protection against MeHg. | Adenosine Triphosphate | interleukin 6 | Mus musculus |