Title : Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses.

Pub. Date : 2013

PMID : 23469045






2 Functional Relationships(s)
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1 In combination with carbachol (10 microM), rivastigmine (1 microM) significantly decreased the release of nitric oxide, TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-activated RAW 264.7 macrophages and this effect was abolished by alpha7 nicotinic receptor blockade by bungarotoxin. Rivastigmine tumor necrosis factor Rattus norvegicus
2 Rivastigmine 1 and 2 mg given rectally to rats with colitis induced by rectal administration of 30 mg dintrobezene sulfonic acid (DNBS) also caused a dose related reduction in ChE activity in blood and colon, the number of ulcers and area of ulceration, levels of TNF-alpha and in MPO activity. Rivastigmine tumor necrosis factor Rattus norvegicus