Title : Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring.

Pub. Date : 2013 Apr

PMID : 23463647






2 Functional Relationships(s)
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1 At weaning, maternal folic acid supplementation significantly decreased global (p < 0.001) and site-specific DNA methylation of the Ppar-gamma, ER-alpha, p53, and Apc genes (p < 0.05) in the liver. Folic Acid peroxisome proliferator-activated receptor gamma Rattus norvegicus
2 At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p < 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p < 0.05). Folic Acid peroxisome proliferator-activated receptor gamma Rattus norvegicus