| Protein Name | peroxisome proliferator-activated receptor gamma |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25664 |
| Gene Symbol | Pparg |
| UniProt | O88275 (PPARG_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
909
Total Number of Articles : 1900 |
Description |
peroxisome proliferator-activated receptor gamma |
| Gene Summary |
Enables several functions, including nuclear estrogen receptor binding activity; protein phosphatase binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to hyperoxia; positive regulation of cell differentiation; and positive regulation of metabolic process. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); glomerulosclerosis; pancreatitis; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Jul 2025] |
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