Pub. Date : 2013 Apr 1
PMID : 23462184
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In summary, the CDK4/cyclin D-pRB axis is altered in MYCN-amplified cells to evade a G(1)-S arrest after doxorubicin-induced DNA damage. | Doxorubicin | RB transcriptional corepressor 1 | Homo sapiens |
| 2 | Additional chromosomal aberrations affecting the p53-p21 and CDK4-pRB axes compound the effects of MYCN on the G(1) checkpoint and reduce sensitivity to cell death after doxorubicin treatment. | Doxorubicin | RB transcriptional corepressor 1 | Homo sapiens |