Title : The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells.

Pub. Date : 2013 Apr 1

PMID : 23460736






2 Functional Relationships(s)
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1 Inhibition of ATM with the highly selective antagonist KU55933 markedly increased IL-23 secretion in human monocyte-derived DC and freshly isolated myeloid DC. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one interleukin 23 subunit alpha Homo sapiens
2 Importantly, ATM inhibition with KU55933 prevented radiation-induced ATM phosphorylation and abrogated the capacity of x-rays to suppress IL-23. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one interleukin 23 subunit alpha Homo sapiens