Title : S100A8 and S100A9 promotes invasion and migration through p38 mitogen-activated protein kinase-dependent NF-κB activation in gastric cancer cells.

Pub. Date : 2013 Mar

PMID : 23456298






3 Functional Relationships(s)
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1 The phosphorylation of p38 MAPK was not affected by the NF-kappaB inhibitor Bay whereas activation of NF-kappaB was blocked by p38 MAPK inhibitor SB203580, indicating that S100A8/A9-induced NF-kappaB activation is mediated by phosphorylation of p38 MAPK. SB 203580 nuclear factor kappa B subunit 1 Homo sapiens
2 The phosphorylation of p38 MAPK was not affected by the NF-kappaB inhibitor Bay whereas activation of NF-kappaB was blocked by p38 MAPK inhibitor SB203580, indicating that S100A8/A9-induced NF-kappaB activation is mediated by phosphorylation of p38 MAPK. SB 203580 nuclear factor kappa B subunit 1 Homo sapiens
3 S100A8/A9-induced cell migration and invasion was inhibited by SB203580 and Bay, suggesting that activation of p38 MAPK and NF-kappaB is involved in the S100A8/A9 induced cell migration and invasion. SB 203580 nuclear factor kappa B subunit 1 Homo sapiens