Pub. Date : 2013 Apr 12
PMID : 23447530
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The inactive [HisB24]-insulin molecule is remarkably rigid due to a tight accommodation of the L-His side chain in the B24 binding pocket that results in the stronger tethering of B25-B28 residues to the protein core. | Histidine | insulin | Homo sapiens |
2 | In contrast, the highly active [D-HisB24]-insulin is more flexible, and the reverse chirality of the B24C(alpha) atom swayed the D-His(B24) side chain into the solvent. | Histidine | insulin | Homo sapiens |