Pub. Date : 1975 Mar 10
PMID : 234470
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence for involvement of protein kinase in the activation by adenosine 3":5"-monophosphate of brain tyrosine 3-monooxygenase. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 2 | Addition of adenosine 3":5"-monophosphate (cAMP) to high speed supernatant preparations obtained from rat brain caused a 3- to 4-fold increase in tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 3 | Addition of adenosine 3":5"-monophosphate (cAMP) to high speed supernatant preparations obtained from rat brain caused a 3- to 4-fold increase in tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Addition of adenosine 3":5"-monophosphate (cAMP) to high speed supernatant preparations obtained from rat brain caused a 3- to 4-fold increase in tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 5 | Addition of adenosine 3":5"-monophosphate (cAMP) to high speed supernatant preparations obtained from rat brain caused a 3- to 4-fold increase in tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 6 | The tyrosine 3-monooxygenase remained in an activated state upon removal of the cAMP by passing the enzyme through a Sephadex G-25 column. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 7 | Substances which inhibit cAMP-dependent protein kinase, namely, EDTA, ADP, and adenosine, and protein kinase modulator, each antagonized the activation of tyrosine 3-monooxygenase produced by cAMP. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 8 | The activation of tyrosine 3-monooxygenase by added cAMP and protein kinase required the presence of ATP and Mg-2+. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 9 | These data suggests that the cAMP activation of tyrosine 3-monooxygenase may be mediated by a cAMP-dependent protein kinase. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |
| 10 | These data suggests that the cAMP activation of tyrosine 3-monooxygenase may be mediated by a cAMP-dependent protein kinase. | Cyclic AMP | tyrosine hydroxylase | Rattus norvegicus |