Title : NF-κB is a critical mediator of BRCA1-induced chemoresistance.

Pub. Date : 2014 Feb 6

PMID : 23435429






1 Functional Relationships(s)
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1 In this study, we demonstrate that following treatment with the DNA-damaging agents, etoposide or camptothecin, BRCA1 is required for the activation of nuclear factor-kappaB (NF-kappaB), and that BRCA1 and NF-kappaB cooperate to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP. Etoposide X-linked inhibitor of apoptosis Homo sapiens