Pub. Date : 2014 Feb 6
PMID : 23435429
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that following treatment with the DNA-damaging agents, etoposide or camptothecin, BRCA1 is required for the activation of nuclear factor-kappaB (NF-kappaB), and that BRCA1 and NF-kappaB cooperate to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP. | Camptothecin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In this study, we demonstrate that following treatment with the DNA-damaging agents, etoposide or camptothecin, BRCA1 is required for the activation of nuclear factor-kappaB (NF-kappaB), and that BRCA1 and NF-kappaB cooperate to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP. | Camptothecin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In this study, we demonstrate that following treatment with the DNA-damaging agents, etoposide or camptothecin, BRCA1 is required for the activation of nuclear factor-kappaB (NF-kappaB), and that BRCA1 and NF-kappaB cooperate to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP. | Camptothecin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | In this study, we demonstrate that following treatment with the DNA-damaging agents, etoposide or camptothecin, BRCA1 is required for the activation of nuclear factor-kappaB (NF-kappaB), and that BRCA1 and NF-kappaB cooperate to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP. | Camptothecin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | The functional relevance of NF-kappaB activation by BRCA1 in response to etoposide and camptothecin is demonstrated by the significantly reduced survival of BRCA1 wild-type cells upon NF-kappaB inhibition. | Camptothecin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | The functional relevance of NF-kappaB activation by BRCA1 in response to etoposide and camptothecin is demonstrated by the significantly reduced survival of BRCA1 wild-type cells upon NF-kappaB inhibition. | Camptothecin | nuclear factor kappa B subunit 1 | Homo sapiens |