Title : Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.

Pub. Date : 2013 Apr 15

PMID : 23418090






2 Functional Relationships(s)
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1 Levels of the oxygen-sensitive HIF-1alpha subunit and expression of HIF target genes were increased in both hypoxic cells and cells treated with ET-1. Oxygen endothelin 1 Rattus norvegicus
2 Both hypoxia and ET-1 also increased HIF-1alpha mRNA expression and decreased mRNA and protein expression of prolyl hydroxylase 2 (PHD2), which is the protein responsible for targeting HIF-1alpha for O(2)-dependent degradation. Oxygen endothelin 1 Rattus norvegicus