Title : Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.

Pub. Date : 2013 Jun

PMID : 23416061






1 Functional Relationships(s)
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1 METHODS: We investigate the mechanisms of Ins2(C96Y)-induced pancreatic ss cell death in vitro and in vivo, using p38 inhibitor (SB203580), MIN6 cell (pancreatic ss cell line), Akita mice and apoptosis signal-regulating kinase 1 (ASK1) knockout mice. SB 203580 insulin 2 Rattus norvegicus