Title : Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells.

Pub. Date : 1990 May 25

PMID : 2341391






1 Functional Relationships(s)
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1 The inhibition of thymidylate synthesis coincided temporally with the rapid intracellular accumulation of H2PteGlu, a known inhibitor of thymidylate synthase. dihydrofolate thymidylate synthetase Homo sapiens