Pub. Date : 2013 May
PMID : 23402786
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin increases liver accumulation of vitamin B12 - an experimental study in rats. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 2 | AIMS/HYPOTHESIS: Patients treated with metformin exhibit low levels of plasma vitamin B12 (B12), and are considered at risk for developing B12 deficiency. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 3 | AIMS/HYPOTHESIS: Patients treated with metformin exhibit low levels of plasma vitamin B12 (B12), and are considered at risk for developing B12 deficiency. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 4 | AIMS/HYPOTHESIS: Patients treated with metformin exhibit low levels of plasma vitamin B12 (B12), and are considered at risk for developing B12 deficiency. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 5 | In this study, we investigated the effect of metformin treatment on B12 uptake and distribution in rats. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 6 | RESULTS: Three weeks of metformin treatment reduced plasma B12 by 22% or 289 [47-383] pmol/L (median and [range]) (p = 0.001), while no effect was observed on unsaturated B12-binding capacity. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 7 | RESULTS: Three weeks of metformin treatment reduced plasma B12 by 22% or 289 [47-383] pmol/L (median and [range]) (p = 0.001), while no effect was observed on unsaturated B12-binding capacity. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 8 | Compared with controls, the amount of B12 in the liver was 36% (p = 0.007) higher in metformin-treated rats, while the B12 content in the kidney was 34% (p = 0.013) lower. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 9 | Compared with controls, the amount of B12 in the liver was 36% (p = 0.007) higher in metformin-treated rats, while the B12 content in the kidney was 34% (p = 0.013) lower. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 10 | CONCLUSIONS/INTERPRETATION: These results show that metformin treatment increases liver accumulation of B12, thereby resulting in decreases in circulating B12 and kidney accumulation of the vitamin. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 11 | CONCLUSIONS/INTERPRETATION: These results show that metformin treatment increases liver accumulation of B12, thereby resulting in decreases in circulating B12 and kidney accumulation of the vitamin. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |
| 12 | Our data questions whether the low plasma B12 observed in patients treated with metformin reflects impaired B12 status, and rather suggests altered tissue distribution and metabolism of the vitamin. | Metformin | NADH:ubiquinone oxidoreductase subunit B3 | Homo sapiens |