Title : Cholesterol loading affects osteoblastic differentiation in mouse mesenchymal stem cells.

Pub. Date : 2013 Apr

PMID : 23395977






1 Functional Relationships(s)
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1 However, the stimulation extent was reduced when incubating the cells with cholesterol plus the ACAT (acyl-CoA:cholesterol acyltransferase) inhibitor Sandoz58035 or SiRNA-ACAT1 [which blocks the esterification of free cholesterol (FC) to cholesteryl ester (CE)], indicating the osteogenic potency of cholesterol was mostly due to CE levels. Cholesterol Esters acetyl-Coenzyme A acetyltransferase 1 Mus musculus