Pub. Date : 2013 May
PMID : 23393219
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin. | repaglinide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
2 | Repaglinide is mainly metabolized by cytochrome P450 enzymes CYP2C8 and CYP3A4, and it is also a substrate to a hepatic uptake transporter, organic anion transporting polypeptide (OATP)1B1. | repaglinide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |