Title : Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.

Pub. Date : 2013 May

PMID : 23393219






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Repaglinide is mainly metabolized by cytochrome P450 enzymes CYP2C8 and CYP3A4, and it is also a substrate to a hepatic uptake transporter, organic anion transporting polypeptide (OATP)1B1. repaglinide solute carrier organic anion transporter family member 1B1 Homo sapiens