Pub. Date : 2013 Apr 9
PMID : 23384965
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity. | Cisplatin | interleukin 6 | Mus musculus |
| 2 | AIMS: We reported that interleukin-6 (IL-6) plays a protective role in the development of cisplatin-induced acute renal failure (ARF) through upregulation of anti-oxidative stress factors. | Cisplatin | interleukin 6 | Mus musculus |
| 3 | AIMS: We reported that interleukin-6 (IL-6) plays a protective role in the development of cisplatin-induced acute renal failure (ARF) through upregulation of anti-oxidative stress factors. | Cisplatin | interleukin 6 | Mus musculus |
| 4 | SIGNIFICANCE: In IL-6(-/-) mice, overproduction of ROS by cisplatin results in upregulation of HO-1 expression in order to eliminate oxidative stress. | Cisplatin | interleukin 6 | Mus musculus |
| 5 | IL-6 mediates the generation and elimination of ROS during cisplatin-induced ARF. | Cisplatin | interleukin 6 | Mus musculus |