Title : Urea's effect on the ribonuclease A catalytic efficiency: a kinetic, 1H NMR and molecular orbital study.

Pub. Date : 2013 Feb

PMID : 23381689






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1 Based in enzyme kinetics experiments and (1)H NMR spectroscopic analysis we proposed that urea, at low concentrations, directly interacts with the protonated histidines of the active center of RNase A, following a simple model of competitive inhibition. Histidine ribonuclease A family member 1, pancreatic Homo sapiens