Pub. Date : 2013 May
PMID : 23376588
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons. | Iron | interleukin 1 beta | Mus musculus |
| 2 | In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons. | Iron | interleukin 1 beta | Mus musculus |
| 3 | The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1). | Iron | interleukin 1 beta | Mus musculus |
| 4 | The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1). | Iron | interleukin 1 beta | Mus musculus |
| 5 | The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1). | Iron | interleukin 1 beta | Mus musculus |
| 6 | Further experiments demonstrated that IL-1beta and TNF-alpha release was remarkably enhanced by iron load in activated microglia triggered by lipopolysaccharide or 1-methyl-4-phenylpyridinium (MPP(+)). | Iron | interleukin 1 beta | Mus musculus |
| 7 | These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production. | Iron | interleukin 1 beta | Mus musculus |
| 8 | These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production. | Iron | interleukin 1 beta | Mus musculus |