Title : Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.

Pub. Date : 2013

PMID : 23363842






1 Functional Relationships(s)
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1 RESULTS: Both indoxyl sulfate and nutlin-3, a specific p53 inducer, stimulated TGF-beta1 expression, which was suppressed by pifithrin-alpha, p-nitro, a p53 inhibitor. nutlin 3 transforming growth factor, beta 1 Rattus norvegicus