Title : In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice.

Pub. Date : 2013 Feb

PMID : 23362873






3 Functional Relationships(s)
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1 The treatment of mice skin with the PPARgamma and PPARalpha agonists, pioglitazone and WY14643, was associated with significant increase in photons emission reaching maximal signalling at 6 h. We have performed dose response studies by testing a large range of pioglitazone and WY14643 concentrations on mouse skin. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
2 The treatment of mice skin with the PPARgamma and PPARalpha agonists, pioglitazone and WY14643, was associated with significant increase in photons emission reaching maximal signalling at 6 h. We have performed dose response studies by testing a large range of pioglitazone and WY14643 concentrations on mouse skin. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
3 The specificity of bioluminescence signal induced by pioglitazone and WY14643 was assessed using PPARgamma and PPARalpha antagonists, GW9662 and GW6471, respectively. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus