Title : Switching p53 states by calcium: dynamics and interaction of stress systems.

Pub. Date : 2013 Mar

PMID : 23360948






1 Functional Relationships(s)
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Protein Name
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1 The high dose of calcium in the system activates the nitric oxide synthase, synthesizing nitric oxide which then downregulates Mdm2 and influences drastically the p53-Mdm2 network regulation, lifting the system from a normal to a stressed state. Nitric Oxide tumor protein p53 Homo sapiens