PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23360948-2 2013 The high dose of calcium in the system activates the nitric oxide synthase, synthesizing nitric oxide which then downregulates Mdm2 and influences drastically the p53-Mdm2 network regulation, lifting the system from a normal to a stressed state. Nitric Oxide 53-65 tumor protein p53 Homo sapiens 163-166