Pub. Date : 2013 Mar
PMID : 23352659
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Immunologically, PBC is distinguished by immune mediated destruction of the intra hepatic bile ducts and the presence of high titer antimitochondrial autoantibodies (AMA) directed against a highly specific epitope within the lipoic acid binding domain of the pyruvate dehydrogenase E2 subunit (PDC-E2). | Thioctic Acid | dihydrolipoamide S-acetyltransferase | Homo sapiens |
| 2 | Immunologically, PBC is distinguished by immune mediated destruction of the intra hepatic bile ducts and the presence of high titer antimitochondrial autoantibodies (AMA) directed against a highly specific epitope within the lipoic acid binding domain of the pyruvate dehydrogenase E2 subunit (PDC-E2). | Thioctic Acid | dihydrolipoamide S-acetyltransferase | Homo sapiens |
| 3 | We submit that in genetically susceptible hosts, electrophilic modification of lipoic acid in PDC-E2 by acetaminophen or similar drugs can facilitate loss of tolerance and lead to the development of PBC. | Thioctic Acid | dihydrolipoamide S-acetyltransferase | Homo sapiens |
| 4 | We submit that in genetically susceptible hosts, electrophilic modification of lipoic acid in PDC-E2 by acetaminophen or similar drugs can facilitate loss of tolerance and lead to the development of PBC. | Thioctic Acid | dihydrolipoamide S-acetyltransferase | Homo sapiens |