Pub. Date : 2013 Feb 11
PMID : 23352126
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. | Phenformin | serine/threonine kinase 11 | Mus musculus |
| 2 | Therapeutic trials in Kras-dependent mouse models of NSCLC revealed that tumors with Kras and Lkb1 mutations, but not those with Kras and p53 mutations, showed selective response to phenformin as a single agent, resulting in prolonged survival. | Phenformin | serine/threonine kinase 11 | Mus musculus |