Title : KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas.

Pub. Date : 2013 May 1

PMID : 23335286






3 Functional Relationships(s)
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1 CONCLUSIONS: KRAS mutations, which were present in approximately 33% of BilIN lesions, occurred as an early molecular event during the progression of BilIN to ICC, whereas p53 overexpression was identified as a late molecular event. Bile Pigments KRAS proto-oncogene, GTPase Homo sapiens
2 CONCLUSIONS: KRAS mutations, which were present in approximately 33% of BilIN lesions, occurred as an early molecular event during the progression of BilIN to ICC, whereas p53 overexpression was identified as a late molecular event. Bile Pigments KRAS proto-oncogene, GTPase Homo sapiens
3 Furthermore, the current results indicted that BilIN also may arise from LBD and PBG lesions in patients who have hepatolithiasis with KRAS mutations. Bile Pigments KRAS proto-oncogene, GTPase Homo sapiens