Title : Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells.

Pub. Date : 2013 Nov

PMID : 23325562






3 Functional Relationships(s)
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1 Also, ursolic acid enhanced the cleavages of poly-ADP-ribose polymerase (PARP) and caspase3, attenuated the expression of astrocyte elevated gene (AEG1) and survivin in HepG2 cells. ursolic acid poly(ADP-ribose) polymerase 1 Homo sapiens
2 Also, ursolic acid enhanced the cleavages of poly-ADP-ribose polymerase (PARP) and caspase3, attenuated the expression of astrocyte elevated gene (AEG1) and survivin in HepG2 cells. ursolic acid poly(ADP-ribose) polymerase 1 Homo sapiens
3 Conversely, AMPK inhibitor compound C or GSK3beta inhibitor SB216763 blocked the cleavages of PARP and caspase 3 induced by ursolic acid in HepG2 cells. ursolic acid poly(ADP-ribose) polymerase 1 Homo sapiens